January 7 — Dáil Éireann, the parliament of the Irish Republic, ratifies the Anglo-Irish Treaty by 64 votes to 57
January 11 — The first successful insulin treatment of diabetes is made, by Frederick Banting in Toronto.
January 15 — Michael Collins becomes Chairman of the Irish Provisional Government
January 28 — Snowfall from the biggest-ever recorded snowstorm in Washington, D.C., causes the roof of the Knickerbocker Theatre to collapse, killing 98.
February 1 — Irish American film director William Desmond Taylor is found murdered at his home in Los Angeles; the case is never solved.
February 2 — Ulysses, by James Joyce, is published in Paris on his 40th birthday by Sylvia Beach.
February 5 — DeWitt and Lila Wallace publish the first issue of Reader’s Digest.
February 6 – Pope Pius XI (Achille Ratti) succeeds Pope Benedict XV, to become the 259th pope.
February 6 – The Five Power Naval Disarmament Treaty is signed between the United States, United Kingdom, Japan, France and Italy.
March 4 — The film Nosferatu is released.
March 10—14 — The Rand Rebellion, a strike by white South African mine workers, becomes open rebellion against the state.
March 15 — Egypt having gained self-government from the United Kingdom, Fuad I becomes King of Egypt.
March 18 — In British India, Mahatma Gandhi is sentenced to six years in prison for sedition (he serves only two).
March 31 — The Hinterkaifeck Murders occur in Germany, on a late evening.
April 3 — Joseph Stalin is appointed General Secretary of the Central Committee of the Soviet Communist Party.
May 3 — Viktor Kingissepp, leader of the underground Estonian Communist Party, is executed in Estonia.
June 11 — Nanook of the North, the first commercially successful feature-length documentary film, premières in the U.S.
June 24 — Weimar Republic foreign minister Walther Rathenau is assassinated.
July 11 — The Hollywood Bowl opens.
August 2 — A typhoon hits Shantou, China, killing more than 5,000 people.
August 22 — Irish Civil War – General Michael Collins is assassinated in West Cork.
September 3 — The Autodromo Nazionale Monza, the world’s third purpose-built motorsport race track, is officially opened at Monza in the Lombardy Region of Italy.
September 9 — Turkish forces pursuing withdrawing Greek troops enter Ä°zmir, effectively ending the Greco-Turkish War (1919—22).
September 13—15 — The Great Fire of Smyrna destroys most of Ä°zmir. Responsibility is disputed.
September 24 (O. S. September 11) – 11 September 1922 Revolution in Greece.
September 29 — Drums in the Night (Trommeln in der Nacht) becomes the first play by Bertolt Brecht to be staged, at the Munich Kammerspiele.
October 15 — T. S. Eliot establishes The Criterion magazine, containing the first publication of his poem The Waste Land.
October 18 — The British Broadcasting Company is formed.
October 25 — The Third Dáil enacts the Constitution of the Irish Free State.
October 28 – In Italy, the March on Rome brings the National Fascist Party and Benito Mussolini to power.
October 28 – The Rose Bowl Stadium officially opened in Pasadena, California
November 1 – The Ottoman Empire is abolished after 600 years, and its last sultan, Mehmed VI, abdicates, leaves for exile in Italy on November 17.
November 21 — Rebecca Felton of Georgia takes the oath of office, becoming the first woman United States Senator.
November 22 – During a 3-day strike action in the city of Guayaquil, Ecuador, police and military fire into a crowd, killing at least 300.
November 24 — Popular author and anti-Treaty Republican Erskine Childers is executed by firing squad in Dublin, for the unlawful possession of a gun presented to him by Michael Collins in 1920
December 6 — The Irish Free State officially comes into existence. George V becomes the Free State’s monarch, and Tim Healy is appointed Governor-General.
December 9 — Gabriel Narutowicz is elected the first president of Poland.
December 16 — Gabriel Narutowicz is assassinated by a right-wing sympathizer in Warsaw.
December 30 — Russia, Ukraine, Belarus and the Transcaucasian Republic come together to form the Union of Soviet Socialist Republics, dissolved in 1991.